Sensoril® – Stress & Anxiety Management

Clinically Proven to:

  1. Reduce Hamilton Anxiety Rating Scale by 62%
  2. Reduce Serum Cortisol (stress hormone) levels by 14.5%
  3. Increase DHEAS (energizing hormone) levels by 13%

 

 

Sensoril® is a standardized extract, derived from the renowned Ayurvedic adaptogenic botanical Ashwagandha (Withania somnifera), that has been qualified to be effectively used in mental performance formulas. Sensoril® is a multi-patented, clinically tested in more than 15 clinical trials, functional ingredient that has been qualified to be effectively used to reduce stress and anxiety, and improving brain health. In a clinical trial that involved 96 healthy volunteers Sensoril® administration resulted to significant reduction in the Hamilton Anxiety Rating Scale (a well validated tool for measuring the severity of patient’s anxiety) by 62%. In the same clinical trial Sensoril® administration reduced serum cortisol levels (stress hormone) by 14,5% and increased serum DHEAS (energizing hormone) by 13%.

 

Sensoril® when used at higher doses (250 mg twice daily) has resulted in significantly greater working memory, reaction time and cognitive capacity when tested with subjects diagnosed with bipolar disorder.

 

Summary of Relevant Clinical Trials:

 

  • In a 60 day, (98 subjects) 4-ARM, parallel study Sensoril® resulted to a statistically significant increase is serum DHEAS and reduction in cortisol (stress hormone), stress, anxiety, irritability, inability to concentrate, forgetfulness, sleeplessness, fatigue, and other subjective indicators of stress at all doses (Auddy B, et al. 2008. A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans; A double-blind, randomized, placebo-controlled study. JANA 11:50-56) – Tested Doses: 125 mg once daily, 125 twice daily
  • In an 8 week (53 subjects diagnosed with bipolar disorder), randomized, double-blind, placebo controlled parallel study Sensoril® in significantly greater working memory, reaction time and cognitive capacity (Chengappa KNR, et al. 2013. Randomized placebo-controlled adjunctive study of an extract of Withania somnifera for cognitive dysfunction in bipolar disorder. J Clin Psych 74(11):1076-1083) – Tested Doses: 250 mg twice daily
  • In a 14 day (20 subjects), randomized, double-blind, placebo-controlled crossover study Sensoril® led to greater working memory, reaction time and ability to process and store information (Pingali U, et al. 2013. Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants. Pharmacogn Res 6(1): 12-18) – Tested Doses: 500 mg twice daily

Sensoril® – Cardiovascular Health

Clinically Proven to:

  1. Reduce total cholesterol by 7%
  2. Reduce triglycerides by 9.5%
  3. Reduce VLDL by 8%
  4. Reduce C-Reactive Protein (a biomarker linked with the occurrence of CVD) by 36%
  5. Reduce systolic blood pressure by 3.4%
  6. Reduce diastolic blood pressure by 5%

 

 

Sensoril® is a standardized extract, derived from the renowned Ayurvedic adaptogenic botanical Ashwagandha (Withania somnifera). Phytoril® is a multi-patented, clinically tested in more than 15 clinical trials, functional ingredient that has been qualified to be effectively used in heart and cardiovascular formulas. In a clinical trial that involved 96 healthy volunteers Sensoril® administration resulted to significant reduction in total cholesterol by 7%, triglyceride by 9.5%, LDL (bad cholesterol) by 8%, VLDL (very bad cholesterol) reduction by 16% and C-reactive protein (a biomarker linked with the occurrence of CVD) by 36%, as well as, systolic and diastolic blood pressure by 3.4% and 5%, respectively.

 

Summary of Relevant Clinical Trials:

 

  • In a 60 day, (98 subjects) 4-ARM, parallel study Sensoril® resulted to a statistically significant reduction in total cholesterol, triglyceride, LDL, VLDL reduction and C-reactive protein. (Auddy B, et al. 2008. A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans; A double-blind, randomized, placebo-controlled study. JANA 11:50-56) – Tested Doses: 125 mg once daily, 125 twice daily
  • In a 14 day, randomized, double-blind, placebo-controlled crossover study with 20 subjects Sensoril® resulted to a significant reduction of blood pressure, C-reactive protein, and MDA (measure of lipid peroxidation). (Pingali U, et al. 2013. Effect of Withania somnifera extract on mental stress induced changes in hemodynamic properties and arterial wave reflections in healthy subjects. Curr Top Nutraceutical Res 11(4):151-158) – Tested Doses: 500 mg twice a day
  • In a 12 week randomized, double-blind, placebo-controlled parallel study with 60 type 2 diabetes patients Sensoril® resulted significant improvement of endothelial function based on reflective index, as well as C-reactive protein, blood lipids and biomarkers of oxidative stress. (Pingali U, et al. 2014. Evaluation of a highly standardized Withania somnifera extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: A randomized, double blind, placebo controlled study. Int J Ayurveda Pharma Res 2(3):22-32) – Tested Doses: 250 mg twice daily, 500 mg twice daily
  • In a 12 week randomized, double-blind, parallel study with 30 type 2 diabetes patients Senosril® resulted significant improvement of endothelial function based on reflective index, as well as C-reactive protein, blood lipids and biomarkers of oxidative stress. (Pingali U, et al. 2014. A comparative study to evaluate the effect of highly standardised aqueous extracts of Phyllanthus emblica, Withania somnifera and their combination on endothelial dysfunction and biomarkers in patients with type II diabetes mellitus. Int J Pharm Sci Res 5(7):2687-2697) – Tested Doses: 500 mg twice a day, 250 mg twice a day
  • In a 14 days (20 subjects), double-blind, placebo controlled, crossover study Sensoril® resulted to a significant decrease in cold pressor stress test induced changes on aortic wave reflections, suggesting beneficial reducing stress-induced cardiovascular changes.  (Pilli R. et al. 2016. Evaluation of effect of highly standardized aqueous extract of roots and leaves of Withania somnifera on cold-pressor test induced cardiovascular changes in healthy human subjects. Int J Bas Clin Pharmcol DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20161538  – Tested Doses: 250 mg twice a day
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